Here, the authors describe an N-heterocyclic carbene and chiral phosphoric acid dual-catalytic process for the desymmetrization of 1,3-diols, to achieve macrocyclization and stereoselective control over two chiral elements.

The ring opening of cyclopropenes provides a compelling platform for the rapid synthesis of various polysubstituted acyclic alkenes, but radical-mediated reactions of this type remain underexplored. Here, the authors report an aminative ring-opening of cyclopropenes with iron-aminyl radical to afford tetrasubstituted alkenyl nitriles.

There is an abundance of solar observational data taken by various instrumentation with different quality and resolutions. Here, the authors provide a deep learning framework for instrument-to-instrument translation of solar observation data, enabling homogenized data series of multi-instrument data sets.

Alcohols are one of the most abundant functional groups in commercially available materials and biologically active compounds. Here, the authors report a metal-free photocatalytic method for the deoxygenative Z-selective olefination of aliphatic alcohols.

The key challenge in CO₂ methanation is achieving efficient CH₄ production at lower temperatures. Here, the authors introduce a Ru catalyst supported on layered Na₂Ti₃O₇, which stabilizes low-valence Ru and facilitates CO₂ activation at low temperatures.

High-resolution hydrodynamic-sediment modeling shows that sediment deposition in Amazonian floodplains is driven by three factors instead of inundation only. Deforestation will reduce the floodplains’ capability to trap sediment over time.

Antibiotic contamination has become a global challenge. Here, authors develop a retrievable and recyclable microalgae hydrogel network system, which can achieve efficient degradation of antibiotics over a wide range of concentrations.

Prenatal exposure to phthalates has been linked to metabolic and neurodevelopmental disruptions but the mechanisms remain unclear. Here, the authors show that prenatal phthalate exposure alters newborn metabolite profiles, particularly in tyrosine and tryptophan pathways, which are associated with infant neurobehavioral outcomes.

The ability to predict wildfires-such as those that recently devastated Los Angeles and Canada-is advancing rapidly with the help of AI. This study shows that to improve accuracy and reliability, we must prioritize the collection and integration of high-quality data.

The strength of the Cape-Horn Current, as traced in the sediment cores, varies with sea surface temperature in the Eastern South Pacific. Changes in this current are also associated with North Hemisphere cooling events and atmospheric CO2 outgassing.

Plant roots are exposed to a diverse range of soil-dwelling microbial “friends” and “foes.” Here, via single-nucleus RNA-seq, the authors reveal cell type-specific responses to beneficial and pathogenic microbes in roots and identify regulators of root-microbiome interactions.

Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate targeting HER2 but paradoxically efficient even in breast cancers expressing HER2 at very low levels. Here authors show that invasive breast cancers, even if their HER2 expression is negligible, secrete extracellular proteases, such as cathepsin L, which cleave the specialized linker of T-DXd, releasing the drug in the tumour microenvironment, while in HER2 positive breast cancers, T-DXd engages Fcγ receptors to promote phagocytosis of HER2-expressing cells and triggers payload-induced immunogenic cell death.

SLC19A1 is crucial for transporting folates, antifolates and cyclic dinucleotides. Here authors determined outward-open structures of hSLC19A1 with and without bound substrates, revealing detailed mechanisms of substrate recognition and conformational changes during transport.

Lfy1 is a maize mutant identified 50 years ago with increased leaf number above the primary ear and later flowering time. Here, the authors reveal that a Copia LTR-retrotransposon insertion leads to enhanced expression of an AAA ATPase encoding gene to give the mutant phenotype.

Single domain antibodies block tau entry into neurons, a key step in tau propagation in the brain in Alzheimer’s disease. They prevent tau from binding to surface receptors by competition. The most effective, VHH H3-2, has a unique binding mode to tau.

Prenatal exposure to phthalates has been linked to metabolic and neurodevelopmental disruptions but the mechanisms remain unclear. Here, the authors show that prenatal phthalate exposure alters newborn metabolite profiles, particularly in tyrosine and tryptophan pathways, which are associated with infant neurobehavioral outcomes.

The suitability of non-invasive surrogate samples for detecting breast cancer remains to be systematically explored. Here, the authors compare non-invasive, non-tumour DNA methylation profiles from cervical, buccal, and blood samples and develop classifiers for breast cancer detection for each sample type.

Aumolertinib is a third generation EGFR tyrosine kinase inhibitors, approved for use in patients with advanced EGFR-mutant non-small cell lung cancer (NSCLC). Here, the authors report a phase 2 clinical trial investigating neoadjuvant aumolertinib in patients with unresectable stage III EGFR-mutant NSCLC.

Recent years have seen an increasing shift from centralized laboratory diagnostics to decentralized point-of-care testing, a shift which has the potential to increase health equity. Here the authors provide their perspective on how the integration of machine learning and artificial intelligence with point-of-care technologies can - and could - support this transition

Discectomy-induced ferroptosis of nucleus pulposus cells (NPCs) contributes to postoperative intervertebral disc degeneration (IDD). Here, Wang et al. report a therapeutic strategy employing ECM-mimetic hydrogel fillers for delivering NPC-derived exosomes to combat ferroptosis-induced IDD.

Antibiotic contamination has become a global challenge. Here, authors develop a retrievable and recyclable microalgae hydrogel network system, which can achieve efficient degradation of antibiotics over a wide range of concentrations.

Global commitments to reducing antimicrobial use in agrifood systems underscore the urgent need to address antimicrobial resistance. Here, the authors project changes in antibiotic use in livestock through 2040, exploring various potential pathways

Enhanced weathering of basalt (EW) removes CO2 chemically, and biotically by enhancing ecosystem growth through phosphorus release. This study shows that leveraging the biotic process can triple the contribution of EW to climate change mitigation.

Achieving the Paris Agreement’s climate goals depends on safeguarding and monitoring the permanence of forest carbon stocks, as delays in addressing their vulnerability to disturbances drastically increase mitigation costs and efforts.

The paper maps air pollution from power plants supplying electricity to US Bitcoin mines. It finds that 1.9 million people in 2022-2023 breathed toxic amounts of Bitcoin mine attributable pollution, particularly around New York City and Houston.